Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …

Osteocytes comprise the overwhelming majority of cells in bone and are its only true
“permanent” resident cell population. In recent years, conceptual and technological …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling
where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation …

Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …

Orthodontic forces deform the extracellular matrix and activate cells of the paradental
tissues, facilitating tooth movement. Discoveries in mechanobiology have illuminated …

Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …

Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment
and adhesion and plays an important role in odontogenesis. In bone, periostin is …