Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

Abstract The World Health Organization has reported approximately 430 million confirmed
cases of coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory …

Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to
correct the causative gene mutation and establish animal models in neurodegenerative …

Abstract Type V and VI CRISPR enzymes are RNA-guided, DNA and RNA-targeting
effectors that allow specific gene knockdown. Cas12 and Cas13 are CRISPR proteins that …

Mutations in specific genes, including synuclein alpha (SNCA) that encodes the α-synuclein
protein, are known to be risk factors for sporadic Parkinson's disease (PD), as well as critical …

With the move of molecular tests from diagnostic labs to on-site testing becoming more
common, there is a sudden rise in demand for nucleic acid-based diagnostic tools that are …

Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive …

Neurological disorders are primarily diseases with sophisticated etiology that are always
refractory and recrudescent. The major obstruction to effective therapies for neurological …

Alpha-synuclein (α-Syn) is a short presynaptic protein with an active role on synaptic vesicle
traffic and the neurotransmitter release and reuptake cycle. The α-Syn pathology intertwines …