[HTML][HTML] Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

A Thakur, DC Parra, P Motallebnejad, M Brocchi… - Bioactive materials, 2022 - Elsevier
Cancer is a deadly disease that is globally and consistently one of the leading causes of
mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy …

Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion

W Tian, N Lei, J Zhou, M Chen, R Guo, B Qin, Y Li… - Cell Death & …, 2022 - nature.com
Chemoresistance and metastasis are the major challenges for the current ovarian cancer
treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is …

Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments

HM Nail, CC Chiu, CH Leung, MMM Ahmed… - Journal of biomedical …, 2023 - Springer
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

Biomembrane-based nanostructures for cancer targeting and therapy: from synthetic liposomes to natural biomembranes and membrane-vesicles

J Wang, M Zhu, G Nie - Advanced drug delivery reviews, 2021 - Elsevier
The translational success of liposomes in chemotherapeutics has already demonstrated the
great potential of biomembrane-based nanostructure in effective drug delivery. Meanwhile …

JAK/STAT signaling: molecular targets, therapeutic opportunities, and limitations of targeted inhibitions in solid malignancies

B Rah, RA Rather, GR Bhat, AB Baba… - Frontiers in …, 2022 - frontiersin.org
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

The role of extracellular vesicles in the hallmarks of cancer and drug resistance

CPR Xavier, HR Caires, MAG Barbosa, R Bergantim… - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …

Exosomal miRNAs in tumor microenvironment

S Tan, L Xia, P Yi, Y Han, L Tang, Q Pan, Y Tian… - Journal of Experimental …, 2020 - Springer
Tumor microenvironment (TME) is the internal environment in which tumor cells survive,
consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non …

Exosomes as biomarkers for female reproductive diseases diagnosis and therapy

S Esfandyari, H Elkafas, RM Chugh, H Park… - International journal of …, 2021 - mdpi.com
Cell–cell communication is an essential mechanism for the maintenance and development
of various organs, including the female reproductive system. Today, it is well-known that the …

Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells

K Pakravan, M Mossahebi-Mohammadi… - Journal of Translational …, 2022 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs), one of the major components of
the tumor stroma, contribute to an immunosuppressive tumor microenvironment (TME) …

Pioneer role of extracellular vesicles as modulators of cancer initiation in progression, drug therapy, and vaccine prospects

S Jahan, S Mukherjee, S Ali, U Bhardwaj… - Cells, 2022 - mdpi.com
Cancer is one of the leading diseases, causing deaths worldwide. Nearly 10 million deaths
were reported in 2020 due to cancer alone. Several factors are involved in cancer …