3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
Three-dimensional genome organization in immune cell fate and function
S Cuartero, G Stik, R Stadhouders - Nature Reviews Immunology, 2023 - nature.com
Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
Genome organization controls transcriptional dynamics during development
Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …
of gene activity. Here, we show through high-resolution chromosome conformation analysis …
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops
The three-dimensional genomic structure plays a critical role in gene expression, cellular
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
B cell progenitor acute lymphoblastic leukemia (B-ALL) treatment has been revolutionized
by T cell-based immunotherapies—including chimeric antigen receptor T cell therapy (CAR …
by T cell-based immunotherapies—including chimeric antigen receptor T cell therapy (CAR …
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency
Transaldolase deficiency predisposes to chronic liver disease progressing from cirrhosis to
hepatocellular carcinoma (HCC). Transition from cirrhosis to hepatocarcinogenesis depends …
hepatocellular carcinoma (HCC). Transition from cirrhosis to hepatocarcinogenesis depends …
BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state
M Xiao, S Kondo, M Nomura, S Kato… - Nature …, 2023 - nature.com
ATP-dependent chromatin remodeling SWI/SNF complexes exist in three subcomplexes:
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …
Mechanisms of Interaction between Enhancers and Promoters in Three Drosophila Model Systems
O Kyrchanova, V Sokolov, P Georgiev - International Journal of Molecular …, 2023 - mdpi.com
In higher eukaryotes, the regulation of developmental gene expression is determined by
enhancers, which are often located at a large distance from the promoters they regulate …
enhancers, which are often located at a large distance from the promoters they regulate …