The incidence of hyperuricemia (HUA) and gout continuously increases and has become a
major public health problem. The gut microbiota, which colonizes the human intestine, has a …

Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a
wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges …

We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR)
in intravascular heme overload whereby hepatocellular export of XOR to the circulation was …

Septic shock currently represents one of the main causes of mortality in critical patient units
with an increase in its incidence in recent years, and it is also associated with a high burden …

Xanthine oxidase (XO) is a flavoprotein that exists in various organisms and can catalyze the
uric acid formation in the human body. Based on the amide framework of N-(4-((3 …

Patient outcomes for severe sepsis and septic shock remain poor. Excessive oxidative stress
accelerates organ dysfunction in severe acute illnesses. Uric acid (UA) is the most abundant …

Xanthine oxidase (XO) utilizes molecular oxygen as a substrate to convert purine substrates
into uric acid, superoxide, and hydrogen peroxide, which is one of the main enzyme …

Our previous work identified a promising isonicotinamide based xanthine oxidase (XO)
inhibitor, N-(3-cyano-4-((2-cyanobenzyl) oxy) phenyl) isonicotinamide (1), and concluded …

Abstract Tripterygium wilfordii Hook. F.(TwHF), a traditional Chinese Medicine, is effective in
treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive …