Background and Purpose: Colorectal cancer (CRC) remains one of the most common
cancer forms developing in industrialized countries, and its incidence appears to be rising …

Intratumour heterogeneity (ITH) and tumour evolution are well‐documented phenomena in
human cancers. While the advent of next‐generation sequencing technologies has …

Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being
mutated in 30–60% of the adenocarcinomas. In this study, 737 incident colorectal cancer …

Background & Aims: Patients with hyperplastic polyposis are reported to have multiple
and/or large hyperplastic polyps (HPs) and an increased risk of colorectal cancer, but the …

Background: Many cancers are attributed to somatic mutation of DNA. We investigated
whether it is feasible to detect cancer-associated somatic mutations in patients with …

Mutations of the TP53 and Ki-ras genes have been reported to be of prognostic importance
in colorectal carcinomas. An increased intracellular concentration of the p53 protein …

To elucidate the role of GNAS mutations in colorectal tumourigenesis, we performed a
mutation analysis in a total of 234 colorectal tumours, including adenomas, serrated lesions …

BACKGROUND The genetic epidemiology of colorectal adenomas has not been studied
prospectively in colonoscopy patients without cancer. AIMS To study genetic alterations in …

Background & Aims: The goal of this study was to examine the relationship between Ki-ras
mutations in colorectal adenomas and characteristics of both the subject (age, gender, and …

Background The early to intermediate stages of the majority of colorectal tumours are
thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A …