Cyclotides: from structure to function

SJ De Veer, MW Kan, DJ Craik - Chemical reviews, 2019 - ACS Publications
This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

The role of antimicrobial peptides in plant immunity

ML Campos, CM de Souza… - Journal of …, 2018 - academic.oup.com
Selective pressure imposed by millions of years of relentless biological attack has led to the
development of an extraordinary array of defense strategies in plants. Among these …

Cysteine‐rich antimicrobial peptides from plants: The future of antimicrobial therapy

S Srivastava, K Dashora, KL Ameta… - Phytotherapy …, 2021 - Wiley Online Library
There has been a spurt in the spread of microbial resistance to antibiotics due to
indiscriminate use of antimicrobial agents in human medicine, agriculture, and animal …

Discovery, structure, function, and applications of cyclotides: circular proteins from plants

J Weidmann, DJ Craik - Journal of Experimental Botany, 2016 - academic.oup.com
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

Natural cyclopeptides as anticancer agents in the last 20 years

JN Zhang, YX Xia, HJ Zhang - International Journal of Molecular Sciences, 2021 - mdpi.com
Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice

HW Wang, WP Zhao, J Liu, PP Tan, C Zhang, BH Zhou - Chemosphere, 2017 - Elsevier
The present study was conducted to investigate the mechanisms of excessive-fluoride-
induced reduction of oocyte development potential in mice. The development morphology of …

Cyclotides: overview and biotechnological applications

A Gould, JA Camarero - ChemBioChem, 2017 - Wiley Online Library
Cyclotides are globular microproteins with a unique head‐to‐tail cyclized backbone,
stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone …

The potential of the cyclotide scaffold for drug development

JA Camarero, MJ Campbell - Biomedicines, 2019 - mdpi.com
Cyclotides are a novel class of micro-proteins (≈ 30–40 residues long) with a unique
topology containing a head-to-tail cyclized backbone structure further stabilized by three …

Plant peptides–redefining an area of ribosomally synthesized and post-translationally modified peptides

JR Chekan, LS Mydy, MA Pasquale… - Natural Product …, 2024 - pubs.rsc.org
Covering 1965 to February 2024Plants are prolific peptide chemists and are known to make
thousands of different peptidic molecules. These peptides vary dramatically in their size …

Recent progress of nano-drug delivery system for liver cancer treatment

F Zhou, F Teng, P Deng, N Meng… - Anti-Cancer Agents in …, 2017 - ingentaconnect.com
Liver cancer is one of serious diseases which threaten human life and health. Studies on the
treatment of liver cancer have attracted widespread attention. Application of nano-drug …