The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Neuroinflammation is an important feature in the pathogenesis and progression of
neurodegenerative diseases such as Alzheimer´ s disease (AD), Parkinson´ s disease (PD) …

A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in
the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …