Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

There is emerging interest in stem cell energy metabolism and its effect on differentiation.
Bioenergetic changes in differentiating bone marrow mesenchymal stem cells (MSCs) are …

Tumors are usually classified into two main categories–benign or malignant, with much
more attention being devoted to the second category given that they are usually associated …

Radiotherapy is a regimen that uses ionising radiation (IR) to treat cancer. Despite the
availability of several therapeutic options, cancer remains difficult to treat and only a minor …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

MicroRNAs (miRNAs) are differentially expressed and play crucial roles in cancer
development and progression. Elevated glycolysis provides survival advantage and …

Background Glioblastoma (GBM) is the most common primary malignant brain tumor that
leads to lethality. Several studies have demonstrated that mitochondria play an important …

The normal cellular function requires communication between mitochondria and the
nucleus, termed mitochondria-to-nucleus retrograde signaling. Disruption of this mechanism …

Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype lacking effective
prognostic indicators or therapeutic targets. Mitochondrial function is dysregulated frequently …