METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development

X Ying, B Liu, Z Yuan, Y Huang, C Chen… - Clinical and …, 2021 - Wiley Online Library
Background The posttranscriptional modifications of transfer RNA (tRNA) are critical for all
aspects of the tRNA function and have been implicated in the tumourigenesis and …

[HTML][HTML] Alterations of chromatin regulators in the pathogenesis of urinary bladder urothelial carcinoma

MJ Hoffmann, WA Schulz - Cancers, 2021 - mdpi.com
Simple Summary Urinary bladder cancer is one of the ten major cancers worldwide, with
higher incidences in males, in smokers, and in highly industrialized countries. New …

[HTML][HTML] Progress in the research and targeted therapy of ErbB/HER receptors in urothelial bladder cancer

D Chen, Y Ye, S Guo, K Yao - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Bladder cancer is a lethal malignancy and a majority of bladder cancer arise from urothelial
cells. Infiltration and metastasis are barriers for the radical cystectomy to achieve favored …

SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling

Z Zhou, Z Zhang, H Chen, W Bao, X Kuang… - British Journal of …, 2022 - nature.com
Background Patients with metastatic bladder cancer have very poor prognosis and
predictive biomarkers are urgently needed for early clinical detection and intervention. In this …

Small‐molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual‐inhibiting properties for bladder cancer treatment

G Li, Z Song, Y Ru, J Zhang, L Luo, W Yang, H Wu… - …, 2023 - Wiley Online Library
Bladder cancer (BCa) is one of the most common malignancies worldwide. Although
multiple efforts have been made, the 5‐year survival rate of patients with BCa remains …

[HTML][HTML] Evaluation of therapeutic targets in histological subtypes of bladder cancer

S Wucherpfennig, M Rose, A Maurer… - International journal of …, 2021 - mdpi.com
Histologically, bladder cancer is a heterogeneous group comprising urothelial carcinoma
(UC), squamous cell carcinoma, adenocarcinomas (ACs), urachal carcinomas (UrCs), and …

[HTML][HTML] MTX-211 inhibits GSH synthesis through Keap1/NRF2/GCLM axis and exerts antitumor effects in bladder cancer

B Hu, R Chen, M Jiang, S Xiong, A Xie, X Liu… - International Journal of …, 2023 - mdpi.com
Globally, bladder cancer (BLCA) is still the leading cause of death in patients with tumors.
The function and underlying mechanism of MTX-211, an EFGR and PI3K kinase inhibitor …

[HTML][HTML] Annexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway

P Li, L Li, Z Li, S Wang, R Li, W Zhao, Y Feng… - Cancer Cell …, 2022 - Springer
Background Bladder cancer (BLCA) is one of the most common malignancies worldwide.
One of the main reasons for the unsatisfactory management of BLCA is the complex …

[HTML][HTML] Prioritization of cancer driver gene with prize-collecting steiner tree by introducing an edge weighted strategy in the personalized gene interaction network

SW Zhang, ZN Wang, Y Li, WF Guo - BMC bioinformatics, 2022 - Springer
Background Cancer is a heterogeneous disease in which tumor genes cooperate as well as
adapt and evolve to the changing conditions for individual patients. It is a meaningful task to …

[HTML][HTML] Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder

V Sauzeau, J Beignet, C Bailly - Biomedicines, 2022 - mdpi.com
Bladder pathologies, very common in the aged population, have a considerable negative
impact on quality of life. Novel targets are needed to design drugs and combinations to treat …