Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria
ultimately disseminate to the lung interstitium. Although various cell types, including alveolar …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Inflammasomes are intracellular complexes involved in the innate immunity that convert
proIL‐1β and proIL‐18 to mature forms and initiate pyroptosis via cleaving procaspase‐1 …

In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL …

Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …

Mycobacterium tuberculosis is a global health problem in part as a result of extensive
cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase …