Radiotherapy and immunology

L Wang, C Lynch, SP Pitroda, A Piffkó, K Yang… - Journal of Experimental …, 2024 - rupress.org
The majority of cancer patients receive radiotherapy during the course of treatment,
delivered with curative intent for local tumor control or as part of a multimodality regimen …

Next-generation combination approaches for immune checkpoint therapy

S Goswami, KE Pauken, L Wang, P Sharma - Nature Immunology, 2024 - nature.com
Immune checkpoint therapy has revolutionized cancer treatment, leading to dramatic clinical
outcomes for a subset of patients. However, many patients do not experience durable …

Stereotactic body radiotherapy with sequential tislelizumab and chemotherapy as neoadjuvant therapy in patients with resectable non-small-cell lung cancer in China …

ZR Zhao, SL Liu, T Zhou, G Chen, H Long… - The Lancet …, 2024 - thelancet.com
Background Neoadjuvant immunotherapy with chemotherapy improves outcomes in
patients with resectable non-small-cell lung cancer (NSCLC). Given its immunomodulating …

[HTML][HTML] Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

T Takaki, R Millar, CT Hiley, SJ Boulton - Molecular Cell, 2024 - cell.com
The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-stimulator of interferon
genes (STING) pathway plays a pivotal role in innate immune responses to viral infection …

Higher immune cell radiation dose is correlated with poor tumor control and survival in patients with non-small cell lung cancer receiving postoperative radiotherapy

Z Ma, Y Liu, Y Bao, Q Liu, X Yang, Y Men, J Wang… - BMC cancer, 2024 - Springer
Introduction The estimated dose of radiation to immune cells (EDRIC) has been shown to
correlate with the overall survival (OS) of patients who receive definitive thoracic …

Lung cancer research and treatment: global perspectives and strategic calls to action

ML Meyer, S Peters, TS Mok, S Lam, PC Yang… - Annals of …, 2024 - Elsevier
Background Lung cancer remains a critical public health issue, presenting multifaceted
challenges in prevention, diagnosis, and treatment. This article aims to review the current …

[HTML][HTML] Reconciling the discrepancies in randomized data of combining immunotherapy and radiation therapy: Not all radiotherapy is created equal

JY Chang, V Verma, RR Weichselbaum - European Journal of Cancer, 2024 - Elsevier
It remains highly unclear and debatable whether combining radiotherapy (RT) and immune
checkpoint blocker (ICB) therapy yields improved outcomes compared to either modality …

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference

PA Laurent, F André, A Bobard, D Deandreis… - …, 2025 - Taylor & Francis
Over the last decade, the annual Immunorad Conference, held under the joint auspicies of
Gustave Roussy (Villejuif, France) and the Weill Cornell Medical College (New-York, USA) …

[HTML][HTML] Immune checkpoint inhibition in early-stage non-small cell lung cancer

K Cuppens, B Du Pont, J Knegjens, B Maes, P Baas - Lung Cancer, 2024 - Elsevier
The introduction of immune checkpoint inhibitors significantly advanced outcomes in both
metastatic and locally advanced non-small cell lung cancer. Despite these advancements …

Advancing neoadjuvant therapies in resectable non-small cell lung cancer: implications for novel treatment strategies and biomarker discovery

H Jeon, R Gor, A D'Aiello, B Stiles, PB Illei… - Pathology and …, 2024 - por-journal.com
The delivery of neoadjuvant and perioperative therapies for non-small cell lung cancer has
been radically altered by significant advances and by the incorporation of targeted therapies …