Impaired wound healing is a major secondary complication of type 2 diabetes that often
results in limb loss and disability. Normal tissue repair progresses through discrete phases …

Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …

Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate–dependent chromatin
remodelers modulate genomic architecture and gene expression and are frequently mutated …

Although SWI/SNF chromatin remodelling complexes are known to regulate diverse
biological functions in plants, the classification, compositions and functional mechanisms of …

CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

Faithful inheritance of parental histones is essential to maintain epigenetic information and
cellular identity during cell division. Parental histones are evenly deposited onto the …

The genetic elements required to tune gene expression are partitioned in active and
repressive nuclear condensates. Chromatin compartments include transcriptional clusters …

Transcription modulated by the circadian clock is diverse across cell types, underlying
circadian control of peripheral metabolism and its observed perturbation in human diseases …