Memory B cells
T Inoue, T Kurosaki - Nature Reviews Immunology, 2024 - nature.com
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
B cell memory: building two walls of protection against pathogens
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
Early precursor T cells establish and propagate T cell exhaustion in chronic infection
DT Utzschneider, SS Gabriel, D Chisanga… - Nature …, 2020 - nature.com
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted'state
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
L Mesin, A Schiepers, J Ersching, A Barbulescu… - Cell, 2020 - cell.com
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
[HTML][HTML] Germinal center B cell dynamics
L Mesin, J Ersching, GD Victora - Immunity, 2016 - cell.com
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …
such are vitally important for humoral immunity. The study of GC biology has undergone a …
[HTML][HTML] Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo
How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity
D Herndler-Brandstetter, H Ishigame, R Shinnakasu… - Immunity, 2018 - cell.com
Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
The generation of antibody-secreting plasma cells
The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …