With aging, incidence of severe stress‐related diseases increases. However, mechanisms,
underlying individual vulnerability to stress and age‐related diseases are not clear. The goal …

Introduction There have been relatively few attempts to quantitatively assess if, and in which
areas, the use of non-animal methods (NAMs) is increasing in biomedical research and …

Major depressive disorder (MDD) is the most severe depression type and one of the leading
causes of morbidity worldwide. Animal models are widely used to understand MDD etiology …

The current paradigm for biomedical research and drug testing postulates that in vitro and in
silico data inform animal studies that will subsequently inform human studies. Recent …

Resumo ISLABÃO, Yan Wahast. Potencial tricomonicida de produtos de origem vegetal:
uma revisão sistemática. 2024. 61f. Dissertação (Mestrado em Ciências Biológicas) …

Gran parte de la toxicidad en pacientes oncológicos tratados con fluoropirimidinas se debe
a la pérdida de la actividad enzimática de la dihidropiridina deshidrogenasa, causada por …

The process of developing and bringing into market new drugs represents one of the
fundamental activities which improves human health and quality of life. The preclinical …

The use of very powerful models can persuade the translation from labs and animal
research as well as the human trials into something simpler, less tedious, and more precise …

Due to the increased rate of infectious diseases, an insufficient number of therapeutics and
antibiotic resistance, the detection of potential sources of novel therapeutic agents is of …

Due to the increased rate of infectious diseases, an insufficient number of therapeutics and
antibiotic resistance, the detection of potential sources of novel therapeutic agents is of …