GABA tone regulation and its cognitive functions in the brain
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
Encouraging an excitable brain state: mechanisms of brain repair in stroke
MT Joy, ST Carmichael - Nature Reviews Neuroscience, 2021 - nature.com
Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …
[HTML][HTML] Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
L Shi, Z Sun, W Su, F Xu, D Xie, Q Zhang, X Dai, K Iyer… - Immunity, 2021 - cell.com
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …
Extracellular vesicle–mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models
L Yang, B Han, Z Zhang, S Wang, Y Bai, Y Zhang… - Circulation, 2020 - Am Heart Assoc
Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate …
quality of life of patients, yet no effective medication currently exists to accelerate …
[HTML][HTML] GABAA receptors: structure, function, pharmacology, and related disorders
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
[HTML][HTML] CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury
MT Joy, EB Assayag, D Shabashov-Stone… - Cell, 2019 - cell.com
We tested a newly described molecular memory system, CCR5 signaling, for its role in
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …
[HTML][HTML] A NeuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion
Adult mammalian brains have largely lost neuroregeneration capability except for a few
niches. Previous studies have converted glial cells into neurons, but the total number of …
niches. Previous studies have converted glial cells into neurons, but the total number of …
Modulation of brain plasticity in stroke: a novel model for neurorehabilitation
Noninvasive brain stimulation (NIBS) techniques can be used to monitor and modulate the
excitability of intracortical neuronal circuits. Long periods of cortical stimulation can produce …
excitability of intracortical neuronal circuits. Long periods of cortical stimulation can produce …
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …