Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in
the world population. Due to specific position of Iran and the presence of multi-ethnic groups …

There is large variation in the molecular genetics and clinical features of
hemoglobinopathies in Iran. Studying structural variants of hemoglobin demonstrated that …

Abstract Alpha-thalassemia (α-thal) is probably the most prevalent monogenic condition in
the world. Deletions are the most common types of mutations in α-thal, followed by point …

Background: Thalassemia syndromes are the most prevalent single gene disorders in Iran.
This study aimed to evaluate the effect of different types of beta-globin gene mutations, co …

Alpha thalassemia is the most prevalent monogenic gene disorder in the world, especially in
Mediterranean countries. In the current hematological phenotype of patients with different …

Abstract α-Thalassemia (α-thal) is one of the most common genetic disorders worldwide.
The aim of this study was to investigate for the first time the α-thal mutation spectrum in the …

Background Thalassaemia is a haemoglobin disorder caused by a reduction in, or a
complete absence of, the production of α-or β-globin genes. Detection of β-thalassaemia …

Despite several studies performed in different provinces of Iran to identify the spectrum of α-
globin gene mutations, no such study has so far been carried out in Ilam Province. A total of …

Abstract α-Thalassemia (α-thal) is the most common monogenic disease that is caused by
the absence or reduced expression of α-globin genes. The aim of this study was to …

Abstract α-Thalassemia (α-thal) encompasses a spectrum of mutations including deletion
and point mutations on the α-globin chains that is characterized by a reduction or complete …