Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors
G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …
infectious disease responsible as the most significant cause of mortality and morbidity …
Defueling the cancer: ATP synthase as an emerging target in cancer therapy
T Wang, F Ma, H Qian - Molecular Therapy-Oncolytics, 2021 - cell.com
Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase
(MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing …
(MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing …
Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa …
Y Zheng, J Chi, J Ou, L Jiang, L Wang… - Advanced …, 2024 - Wiley Online Library
The development of narrow‐spectrum antimicrobial agents is paramount for swiftly
eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the …
eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the …
Inhibitory mechanism of Salmonella Derby biofilm formation by sub-inhibitory concentrations of clove and oregano essential oil: A global transcriptomic study
The present study aimed to investigate the inhibition of clove essential oil (CEO) and
oregano essential oil (OEO) on Salmonella Derby biofilm formation and explore the …
oregano essential oil (OEO) on Salmonella Derby biofilm formation and explore the …
Cytotoxic and antimicrobial mycophenolic acid derivatives from an endophytic fungus Penicillium sp. MNP–HS–2 associated with Macrozamia communis
Macrozamia communis and its associated endophytic fungi are untapped sources of
bioactive metabolites with great potential for medicinal exploitation. Chemical investigation …
bioactive metabolites with great potential for medicinal exploitation. Chemical investigation …
An overview of ATP synthase, inhibitors, and their toxicity
AR Althaher, M Alwahsh - Heliyon, 2023 - cell.com
Mitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in
generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism …
generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism …
From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance
JA Delbrouck, A Murza, I Diachenko, AB Jamaa… - European Journal of …, 2023 - Elsevier
Antibiotic resistance is escalating alarmingly worldwide. Bacterial resistance mechanisms
are surfacing and proliferating across the globe, jeopardizing our capacity to manage …
are surfacing and proliferating across the globe, jeopardizing our capacity to manage …
Synthetic approaches towards bedaquiline and its derivatives
MB Calvert, DP Furkert, CB Cooper… - Bioorganic & Medicinal …, 2020 - Elsevier
Bedaquiline is a diarylquinoline drug that demonstrates potent and selective inhibition of
mycobacterial ATP synthase, and is clinically administered for the treatment of multi-drug …
mycobacterial ATP synthase, and is clinically administered for the treatment of multi-drug …
Insect venom peptides as potent inhibitors of Escherichia coli ATP synthase
A Amini, S Raheem, A Steiner, F Deeba… - International journal of …, 2020 - Elsevier
Insect venom peptides (IVPs) eumenitin, lasiocepsin, lycosin1, mastoparanB, panurgine1,
and protonectin possess antibacterial properties, and the ubiquitous enzyme ATP synthase …
and protonectin possess antibacterial properties, and the ubiquitous enzyme ATP synthase …
Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of …
F1FO-ATP synthase is the mitochondrial complex responsible for ATP production. During
myocardial ischemia, it reverses its activity, hydrolyzing ATP and leading to energetic deficit …
myocardial ischemia, it reverses its activity, hydrolyzing ATP and leading to energetic deficit …