Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

Electrospinning is a highly versatile technology to process polymers or related materials into
fibrous materials with diameters ranging from micrometer to nanometer scale. In the early …

Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …

Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-
renewal. In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell …

Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether
microRNA and protein cell fate determinants coordinate with each other remains unclear …

Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem
cells (CSCs) that participate in tumor propagation, resistance to conventional therapy, and …

Many tumors are hierarchically organized with a minority cell population that has stem-like
properties and enhanced ability to initiate tumorigenesis and drive therapeutic relapse …

Cellular senescence contributes to aging and decline in tissue function. p53 isoform
switching regulates replicative senescence in cultured fibroblasts and is associated with …

Cancer stem cells (CSC) are rare drug-resistant cancer cell subsets proposed to be
responsible for the maintenance and recurrence of cancer and metastasis. Telomerase is …

Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue
survival of stress, but the molecular mechanisms are incompletely understood. We now …