Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Purpose: The study aim to identify novel molecular subtypes of ovarian cancer by gene
expression profiling with linkage to clinical and pathologic features. Experimental Design …

Cells grown in vitro are dramatically perturbed by their new microenvironment. Analyses of
genome-wide gene expression levels offer a first glance at which genes and pathways are …

Among the genes most commonly identified in gene expression profiles of epithelial ovarian
carcinomas (EOC) is the gene for human epididymis protein 4 (HE4). To ascertain its clinical …

Many studies have used DNA microarrays to identify the gene expression signatures of
human cancer, yet the critical features of these often unmanageably large signatures remain …

Abstract The HE4 (WFDC2) gene encodes a WAP-type four disulphide core domain-
containing protein with a presumptive role in natural immunity. Multiple studies have …

Epithelial ovarian cancers can be divided into the more common, aggressive type II cancers
and the less common, slow-growing type I cancers. Under this model, serous ovarian …

A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not
only resemble its tumour of origin at the molecular level, but also demonstrate functional …

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …