Signaling pathways in melanogenesis

SAN D'Mello, GJ Finlay, BC Baguley… - International journal of …, 2016 - mdpi.com
Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

Melanins and melanogenesis: from pigment cells to human health and technological applications

M d'Ischia, K Wakamatsu, F Cicoira… - Pigment cell & …, 2015 - Wiley Online Library
During the past decade, melanins and melanogenesis have attracted growing interest for a
broad range of biomedical and technological applications. The burst of polydopamine …

Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares

MR Jones, LS Mills, PC Alves, CM Callahan, JM Alves… - Science, 2018 - science.org
Snowshoe hares (Lepus americanus) maintain seasonal camouflage by molting to a white
winter coat, but some hares remain brown during the winter in regions with low snow cover …

Melanocortin 1 receptor: structure, function, and regulation

EM Wolf Horrell, MC Boulanger, JA D'Orazio - Frontiers in genetics, 2016 - frontiersin.org
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

The genetics of human skin and hair pigmentation

WJ Pavan, RA Sturm - Annual review of genomics and human …, 2019 - annualreviews.org
Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

“Transcription physiology” of pigment formation in melanocytes: central role of MITF

J Vachtenheim, J Borovanský - Experimental dermatology, 2010 - Wiley Online Library
Please cite this paper as:“Transcription physiology” of pigment formation in melanocytes:
central role of (MITF). Experimental Dermatology 2010; 19: 617–627. Abstract: Melanin …

What are melanocytes really doing all day long…?

PM Plonka, T Passeron, M Brenner… - Experimental …, 2009 - Wiley Online Library
Everyone knows and seems to agree that melanocytes are there to generate melanin–an
intriguing, but underestimated multipurpose molecule that is capable of doing far more than …

Molecular genetics of human pigmentation diversity

RA Sturm - Human molecular genetics, 2009 - academic.oup.com
The genetic basis underlying normal variation in the pigmentary traits of skin, hair and eye
colour has been the subject of intense research directed at understanding the diversity seen …

MC 1R, the c AMP pathway, and the response to solar UV: Extending the horizon beyond pigmentation

JC García‐Borrón, Z Abdel‐Malek… - Pigment cell & …, 2014 - Wiley Online Library
The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Signaling pathways in melanosome biogenesis and pathology

MV Schiaffino - The international journal of biochemistry & cell biology, 2010 - Elsevier
Melanosomes are the specialized intracellular organelles of pigment cells devoted to the
synthesis, storage and transport of melanin pigments, which are responsible for most visible …