Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Corneal nerves and their role in dry eye pathophysiology

A Vereertbrugghen, JG Galletti - Experimental Eye Research, 2022 - Elsevier
As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Coexistence of neuropathic corneal pain, corneal nerve abnormalities, depression, and low quality of life

A Leonardi, OM Feuerman, E Salami, D Lazzarini… - Eye, 2024 - nature.com
Purpose To evaluate the quality of life (QoL), mental health conditions and corneal
morphology in neuropathic corneal pain (NCP) subjects without a significant ocular surface …

In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy

J Luzu, A Labbé, A Réaux-Le Goazigo, G Rabut… - The Ocular Surface, 2022 - Elsevier
Purpose To study changes in the subbasal nerve plexus by In vivo confocal microscopy
(IVCM) in Sjögren's Syndrome (SS) with or without associated Small Fiber Neuropathy …

[HTML][HTML] Clinical associations of corneal neuromas with ocular surface diseases

CJL Toh, C Liu, IXY Lee, MTY Lin… - Neural Regeneration …, 2024 - journals.lww.com
Corneal neuromas, also termed microneuromas, refer to microscopic, irregularly-shaped
enlargements of terminal subbasal nerve endings at sites of nerve damage or injury. The …

Transient Receptor Potential Vanilloid-1 Channels Facilitate Axonal Degeneration of Corneal Sensory Nerves in Dry Eye

M Pizzano, A Vereertbrugghen, A Cernutto… - The American Journal of …, 2024 - Elsevier
Corneal nerve impairment contributes significantly to dry eye disease (DED) symptoms and
is thought to be secondary to corneal epithelial damage. Transient receptor potential …

Corneal nerve abnormalities in painful dry eye disease patients

A Guerrero-Moreno, H Liang, N Moreau, J Luzu… - Biomedicines, 2021 - mdpi.com
Background: This study aimed to compare the corneal nerve structural abnormalities
detected using in vivo confocal microscopy (IVCM) in patients with neuropathic corneal pain …

The utility of oral vitamin B1 and mecobalamin to improve corneal nerves in dry eye disease: an in vivo confocal microscopy study

X Ren, Y Chou, Y Wang, D Jing, Y Chen, X Li - Nutrients, 2022 - mdpi.com
Our purpose is to demonstrate the changes in cornea nerve parameters and symptoms and
signs in dry eye disease (DED) patients after oral vitamin B1 and mecobalamin treatment. In …

Neuropathic corneal pain as debilitating manifestation of long-COVID

JN Woltsche, J Horwath-Winter, C Dorn… - Ocular Immunology …, 2023 - Taylor & Francis
This report illustrates the case of a female patient suffering from severe ocular discomfort,
tinnitus and ageusia, 7 months after a SARS-CoV-2 infection. The medical history implicated …

Redefining our vision: an updated guide to the ocular immune system

M Wu, EL Fletcher, HR Chinnery, LE Downie… - Nature Reviews …, 2024 - nature.com
Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …