Genomic sequencing reveals similar but limited numbers of protein-coding genes in different
genomes, which begs the question of how organismal diversities are generated. Alternative …

Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety
of physiological and environmental insults including anticancer chemotherapy, thus allowing …

In response to physical and chemical stresses that affect protein folding and, thus, the
execution of normal metabolic processes, cells activate gene-expression strategies aimed at …

Phosphorylation is essential for the SR family of splicing factors/regulators to function in
constitutive and regulated pre-mRNA splicing; yet both hypo-and hyperphosphorylation of …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

Cells possess effective mechanisms to cope with chronic or acute disturbance of homeo-
stasis. Key roles in maintaining or restoring homeostasis are played by the various heat …

An estimated one-third of all proteins in higher eukaryotes are regulated by phosphorylation
by protein kinases (PKs). Although plant genomes encode more than 1000 PKs, the …

Background: The HSPB family is one of the more diverse families within the group of HSP
families. Some members have chaperone-like activities and/or play a role in cytoskeletal …

Alternative splicing (AS) is a major mechanism for gene expression in eukaryotes,
increasing proteome diversity but also regulating transcriptome abundance. High …

Previously, we identified the stress-induced chaperone, Hsp27, as highly overexpressed in
castration-resistant prostate cancer and developed an Hsp27 inhibitor (OGX-427) currently …