There has been a dramatic increase in the number of insect-specific flaviviruses (ISFs)
discovered in the last decade. Historically, these viruses have generated limited interest due …

Arthropod-borne viruses (arboviruses), especially those transmitted by mosquitoes, are a
significant cause of morbidity and mortality in humans and animals worldwide. Recent …

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …

During investigations into an outbreak of egg production decline, retarded growth, and even
death among ducks in Southeast China, a novel Tembusu virus strain named Tembusu virus …

We established a laboratory colony of Culex pipiens mosquitoes from eggs collected in
Colorado and discovered that mosquitoes in the colony are naturally infected with Culex …

Recent reports of a novel group of flaviviruses that replicate only in mosquitoes and appear
to spread through insect populations via vertical transmission have emerged from around …

Highlights•ISVs are novel RNA viruses associated with hematophagous insects.•Belong in
diverse families such as Bunyaviridae, Mesoviviridae, and Rhabdoviridae.•Little is known …

Flaviviruses such as dengue, yellow fever, Zika, West Nile, and Japanese encephalitis virus
present substantial global health burdens. New vaccines are being sought to address safety …

Most alphaviruses and many other arboviruses are mosquito-borne and exhibit a broad host
range, infecting many different vertebrates including birds, rodents, equids, humans, and …

Nhumirim virus (NHUV) is an insect-specific virus that phylogenetically affiliates with dual-
host mosquito-borne flaviviruses. Previous in vitro co-infection experiments demonstrated …