[PDF][PDF] Bone morphogenetic proteins: From discovery to development of a novel autologous bone graft substitute consisting of recombinant human BMP6 delivered in …

S Vukičević - This is an open-access article distributed under the …, 2020 - rad-med.com
Bone Morphogenetic Proteins (BMPs) are growth and differentiation factors within the TGFβ
superfamily of proteins. They induce ectopic and orthotopic endochondral bone formation …

Delayed inhibition of collagen deposition by targeting bone morphogenetic protein 1 promotes recovery after spinal cord injury

Y Huang, P Gao, T Qin, B Chu, T Xu, J Yi, Q Wang… - Matrix Biology, 2023 - Elsevier
Fibrotic scars appear after spinal cord injury (SCI) and are mainly composed of fibroblasts
and excess extracellular matrix (ECM), including different types of collagen. The temporal …

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

J Leslie, MG Macia, S Luli, JC Worrell, WJ Reilly… - Nature …, 2020 - nature.com
Fibrosis is a common pathological feature of chronic disease. Deletion of the NF-κB subunit
c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is …

[HTML][HTML] The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen

F Revert-Ros, I Ventura, JA Prieto-Ruiz… - International Journal of …, 2024 - mdpi.com
Collagen, a versatile family of proteins with 28 members and 44 genes, is pivotal in
maintaining tissue integrity and function. It plays a crucial role in physiological processes …

[HTML][HTML] Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction

S Vukicevic, A Colliva, V Kufner, V Martinelli… - Nature …, 2022 - nature.com
Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based
treatment currently exists. Starting from the evidence that a specific isoform of the Bone …

Characterization and role of collagen gene expressing hepatic cells following partial hepatectomy in mice

Y Kimura, Y Koyama, K Taura, A Kudoh, K Echizen… - Hepatology, 2023 - journals.lww.com
Characterization and role of collagen gene expressing hepati... : Hepatology Characterization
and role of collagen gene expressing hepatic cells following partial hepatectomy in mice …

[HTML][HTML] In vivo investigation of the anti-liver fibrosis impact of Balanites aegyptiaca/chitosan nanoparticles

N Zein, F Yassin, HG Ayoub, YHA Elewa… - Biomedicine & …, 2024 - Elsevier
Balanites aegyptiaca (B. aegyptiaca) is an African herb with traditional medical applications.
Various pathogenic factors cause hepatic fibrosis and require novel treatment alternatives …

BMP1 inhibitor UK383, 367 attenuates renal fibrosis and inflammation in CKD

M Bai, J Lei, S Wang, D Ding, X Yu… - American Journal …, 2019 - journals.physiology.org
Renal fibrosis is a key pathological phenomenon of chronic kidney disease (CKD)
contributing to the progressive loss of renal function. UK383, 367 is a procollagen C …

[HTML][HTML] BMP1 is not required for lung fibrosis in mice

HY Ma, EN N'Diaye, P Caplazi, Z Huang, A Arlantico… - Scientific reports, 2022 - nature.com
Abstract Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like
family of zinc metalloproteinases, which play a fundamental role in the development and …

The effect of Lecithins coupled Decorin Nanoliposomes on treatment of carbon tetrachloride‐induced liver fibrosis

G Chen, Y Zhu, X Liang, X Wang, W Yu… - BioMed Research …, 2020 - Wiley Online Library
This study aimed to investigate the effect of bile duct‐targeting lecithins‐(PC‐) coupled
decorin (DCN)(PC‐DCN) nanoliposomes against liver fibrosis in vitro and in vivo. We …