Convergent evolution of toxin resistance in animals

J van Thiel, MA Khan, RM Wouters, RJ Harris… - Biological …, 2022 - Wiley Online Library
Convergence is the phenomenon whereby similar phenotypes evolve independently in
different lineages. One example is resistance to toxins in animals. Toxins have evolved …

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

K Arbuckle, RCR de la Vega, NR Casewell - Toxicon, 2017 - Elsevier
Understanding how biotic interactions shape the genomes of the interacting species is a
long-sought goal of evolutionary biology that has been hampered by the scarcity of tractable …

Natural phospholipase A2 myotoxin inhibitor proteins from snakes, mammals and plants

S Lizano, G Domont, J Perales - Toxicon, 2003 - Elsevier
A renewed interest in the phenomenon of inter-and intra-species resistance towards the
toxicity of snake venoms, coupled with the search for new strategies for treatment of snake …

Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2

MH Borges, AM Soares, VM Rodrigues… - … and Physiology Part B …, 2000 - Elsevier
The crude aqueous extract from the leaves of Casearia sylvestris, a plant found in Brazilian
open pastures, was assayed for its ability to inhibit phospholipase A2 (PLA2) activity and …

Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae)

MH Borges, AM Soares, VM Rodrigues, F Oliveira… - Toxicon, 2001 - Elsevier
Aqueous extract from Casearia sylvestris leaves, a typical plant from Brazilian open
pastures, was able to neutralize the hemorrhagic activity caused by Bothrops asper …

The molecular basis of venom resistance in a rattlesnake‐squirrel predator‐prey system

HL Gibbs, L Sanz, A Pérez, A Ochoa… - Molecular …, 2020 - Wiley Online Library
Understanding how interspecific interactions mould the molecular basis of adaptations in
coevolving species is a long‐sought goal of evolutionary biology. Venom in predators and …

Snake venom phospholipase A2 inhibitors: medicinal chemistry and therapeutic potential

S Marcussi, CD Sant'Ana, CZ Oliveira… - Current topics in …, 2007 - ingentaconnect.com
Phospholipases A2 (PLA2s) are commonly found in snake venoms from Viperidae,
Hydrophidae and Elaphidae families and have been extensively studied due to their …

Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine

JC Pérez, EE Sánchez - Toxicon, 1999 - Elsevier
Snake venoms are complex mixtures of many toxins and enzymes which effectively
immobilize prey without a struggle and assist in digestion. Certain animals have a …

Natural inhibitors of snake venom hemorrhagic metalloproteinases

J Perales, AGC Neves-Ferreira, RH Valente… - Toxicon, 2005 - Elsevier
Metalloproteinases play an important role in the poisoning process by snake venoms. They
evoke systemic injury, by degrading or activating host blood factors, and local damage by …