Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

CLA Bassetti, A Adamantidis, D Burdakov… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

European guideline and expert statements on the management of narcolepsy in adults and children

CLA Bassetti, U Kallweit, L Vignatelli… - European journal of …, 2021 - Wiley Online Library
Background and aim Narcolepsy is an uncommon hypothalamic disorder of presumed
autoimmune origin that usually requires lifelong treatment. This paper aims to provide …

The immunopathogenesis of narcolepsy type 1

RS Liblau, D Latorre, BR Kornum… - Nature Reviews …, 2024 - nature.com
Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

T cells in patients with narcolepsy target self-antigens of hypocretin neurons

D Latorre, U Kallweit, E Armentani, M Foglierini, F Mele… - Nature, 2018 - nature.com
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce
hypocretin. The close association with HLA-DQB1* 06: 02, evidence for immune …

Narcolepsy

TE Scammell - New England Journal of Medicine, 2015 - Mass Medical Soc
Narcolepsy | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …

[HTML][HTML] Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy

JB Stephansen, AN Olesen, M Olsen, A Ambati… - Nature …, 2018 - nature.com
Abstract Analysis of sleep for the diagnosis of sleep disorders such as Type-1 Narcolepsy
(T1N) currently requires visual inspection of polysomnography records by trained scoring …

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

A Seifinejad, M Ramosaj, L Shan, S Li… - Proceedings of the …, 2023 - National Acad Sciences
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …

The neurobiological basis of narcolepsy

CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Narcolepsy

BR Kornum, S Knudsen, HM Ollila, F Pizza… - Nature reviews Disease …, 2017 - nature.com
Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is
characterized by excessive daytime sleepiness, which can have severe consequences for …

[HTML][HTML] Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts

GJ Lammers, CLA Bassetti, L Dolenc-Groselj… - Sleep medicine …, 2020 - Elsevier
The aim of this European initiative is to facilitate a structured discussion to improve the next
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …