Dysfunction of the diaphragm

FD McCool, GE Tzelepis - New England Journal of Medicine, 2012 - Mass Medical Soc
Dysfunction of one or both hemidiaphragms is an underdiagnosed cause of dyspnea.
Weakness or paralysis may be seen during mechanical ventilation, after surgery or trauma …

Intermittent hypoxia and neurorehabilitation

EJ Gonzalez-Rothi, KZ Lee, EA Dale… - Journal of applied …, 2015 - journals.physiology.org
In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill

O Peñuelas, E Keough, L López-Rodríguez… - Intensive care medicine …, 2019 - Springer
Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients
incapable of adequately ventilating and/or oxygenating due to respiratory or other disease …

Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia

NO Barioni, F Derakhshan, L Tenorio Lopes… - Science …, 2022 - science.org
As blood oxygenation decreases (hypoxemia), mammals mount cardiorespiratory
responses, increasing oxygen to vital organs. The carotid bodies are the primary oxygen …

Diaphragmatic palsy

L Kokatnur, M Rudrappa - Diseases, 2018 - mdpi.com
The diaphragm is the primary muscle of respiration, and its weakness can lead to respiratory
failure. Diaphragmatic palsy can be caused by various causes. Injury to the phrenic nerve …

Phrenic nerve stimulation in patients with spinal cord injury

AF DiMarco - Respiratory physiology & neurobiology, 2009 - Elsevier
Phrenic nerve pacing (PNP) is a clinically useful technique to restore inspiratory muscle
function in patients with respiratory failure secondary to cervical spinal cord injury. In this …

Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation

MD Sunshine, AM Cassarà, E Neufeld… - Communications …, 2021 - nature.com
Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular
disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could …

Acute spinal cord injury: tetraplegia and paraplegia in small animals

N Granger, D Carwardine - Veterinary clinics: small animal …, 2014 - vetsmall.theclinics.com
Videos of:(1) extension of the digits in response to stimulation of the plantar surface in a dog
following severe SCI;(2) 5-year-old male neutered paraplegic Dachshund showing evidence …

The phrenic neuromuscular system

DD Fuller, S Rana, AJ Smuder, EA Dale - Handbook of clinical neurology, 2022 - Elsevier
The phrenic neuromuscular system consists of the phrenic motor nucleus in the mid-cervical
spinal cord, the phrenic nerve, and the diaphragm muscle. This motor system helps sustain …

Upper-limb muscle responses to epidural, subdural and intraspinal stimulation of the cervical spinal cord

AN Sharpe, A Jackson - Journal of neural engineering, 2014 - iopscience.iop.org
Objective. Electrical stimulation of the spinal cord has potential applications following spinal
cord injury for reanimating paralysed limbs and promoting neuroplastic changes that may …