Benzodiazepines revisited—will we ever learn?

M Lader - Addiction, 2011 - Wiley Online Library
Aims To re‐examine various aspects of the benzodiazepines (BZDs), widely prescribed for
50 years, mainly to treat anxiety and insomnia. It is a descriptive review based on the Okey …

Benzodiazepine use and risk of dementia in the elderly population: a systematic review and meta-analysis

MM Islam, U Iqbal, B Walther, S Atique, NK Dubey… - …, 2017 - karger.com
Background: Benzodiazepines are a widely used medication in developed countries,
particularly among elderly patients. However, benzodiazepines are known to affect memory …

[PDF][PDF] Benzodiazepine use and risk of Alzheimer's disease: case-control study

SB De Gage, Y Moride, T Ducruet, T Kurth, H Verdoux… - Bmj, 2014 - bmj.com
Objectives To investigate the relation between the risk of Alzheimer's disease and exposure
to benzodiazepines started at least five years before, considering both the dose-response …

Benzodiazepine use and risk of dementia: prospective population based study

SB de Gage, B Bégaud, F Bazin, H Verdoux… - Bmj, 2012 - bmj.com
Objective To evaluate the association between use of benzodiazepines and incident
dementia. Design Prospective, population based study. Setting PAQUID study, France …

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

SL Gray, S Dublin, O Yu, R Walker, M Anderson… - bmj, 2016 - bmj.com
Objective To determine whether higher cumulative use of benzodiazepines is associated
with a higher risk of dementia or more rapid cognitive decline. Design Prospective …

Psychological burden of PTSD, depression, and their comorbidity in the US veteran population: Suicidality, functioning, and service utilization

B Nichter, S Norman, M Haller, RH Pietrzak - Journal of affective disorders, 2019 - Elsevier
Background Emerging evidence suggests that comorbid posttraumatic stress disorder
(PTSD) and major depressive disorder (PTSD/MDD) may impose an even greater burden …

Benzodiazepine harm: how can it be reduced?

M Lader - British journal of clinical pharmacology, 2014 - Wiley Online Library
The benzodiazepines (BZDs) are anxiolytics, hypnotics, anticonvulsants, muscle‐relaxants
and induce anaesthesia. Adverse effects comprise sedation subjectively and cognitive and …

[HTML][HTML] Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: a systematic review and meta-analysis …

DM Sumsuzzman, J Choi, Y Jin, Y Hong - Neuroscience & Biobehavioral …, 2021 - Elsevier
Endogenous melatonin levels are inversely associated with age and cognitive deficits.
Although melatonin can improve psychopathological behavior disturbances in clinical trials …

Benzodiazepine use and cognitive decline in the elderly

JD Picton, AB Marino, KL Nealy - The Bulletin of the American …, 2018 - academic.oup.com
Purpose Published evidence on the relationship between benzodiazepine exposure and
altered cognition in the geriatric population is reviewed. Summary Benzodiazepines …

Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression

M Boldrini, R Hen, MD Underwood, GB Rosoklija… - Biological …, 2012 - Elsevier
BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the
dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in …