Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

Oral cavity carcinomas are the most frequent malignancies among head and neck
malignancies. Oral tumors include not only oral cancer cells with different potency and …

Under nonpathological conditions, the extracellular nucleotide concentration remains
constant and low (nM range) because of a close balance between ATP release and ATP …

Regardless of improved biological insights and therapeutic advances, cancer is consuming
multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and …

A 2B adenosine receptors are present in a wide spectrum of tissues, especially on cells of
the immune system. Since these particular receptors have the lowest, of all adenosine …

Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant
treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …

The purinergic system is fundamental in the tumor microenvironment, since it regulates
tumor cell interactions with the immune system, as well as growth and differentiation in …

Simple Summary Bruton's Tyrosine Kinase (BTK) was originally considered to be primarily
expressed in cells of hematopoietic origin. Apart from the 77 kDa BTK isoform expressed in …

A key objective in immuno-oncology is to reactivate the dormant immune system and
increase tumour immunogenicity. Adenosine is an omnipresent purine that is formed in …