Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

How a complex animal can arise from a fertilized egg is one of the oldest and most
fascinating questions of biology, the answer to which is encoded in the genome. Body shape …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Rare copy-number variants (rCNVs) include deletions and duplications that occur
infrequently in the global human population and can confer substantial risk for disease. In …

Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Deep transcriptome sequencing has revealed the existence of many transcripts that lack
long or conserved open reading frames (ORFs) and which have been termed long non …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

The architecture of human chromosomes in interphase nuclei is still largely unknown.
Microscopy studies have indicated that specific regions of chromosomes are located in close …

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris),
together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The …

We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the
chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to …