Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, p …
M DiNuzzo, GA Dienel, KL Behar… - Journal of …, 2024 - Wiley Online Library
During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
[HTML][HTML] Cerebrovascular blood flow design and regulation; vulnerability in aging brain
DF Wilson, FM Matschinsky - Frontiers in Physiology, 2020 - frontiersin.org
Nutrient delivery to the brain presents a unique challenge because the tissue functions as a
computer system with in the order of 200,000 neurons/mm3. Penetrating arterioles bud from …
computer system with in the order of 200,000 neurons/mm3. Penetrating arterioles bud from …
[HTML][HTML] From a demand-based to a supply-limited framework of brain metabolism
S Herculano-Houzel, DL Rothman - Frontiers in Integrative …, 2022 - frontiersin.org
What defines the rate of energy use by the brain, as well as per neurons of different sizes in
different structures and animals, is one fundamental aspect of neuroscience for which much …
different structures and animals, is one fundamental aspect of neuroscience for which much …
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation
The cerebral cortex has a number of conserved morphological and functional characteristics
across brain regions and species. Among them, the laminar differences in microvascular …
across brain regions and species. Among them, the laminar differences in microvascular …
[HTML][HTML] Baseline oxygen consumption decreases with cortical depth
P Mächler, N Fomin-Thunemann, M Thunemann… - PLoS …, 2022 - journals.plos.org
The cerebral cortex is organized in cortical layers that differ in their cellular density,
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
[HTML][HTML] Neurovascular reactivity in the aging mouse brain assessed by laser speckle contrast imaging and 2-photon microscopy: quantification by an investigator …
FB Seker, Z Fan, B Gesierich, M Gaubert… - Frontiers in …, 2021 - frontiersin.org
The brain has a high energy demand but little to no energy stores. Therefore, proper brain
function relies on the delivery of glucose and oxygen by the cerebral vasculature. The …
function relies on the delivery of glucose and oxygen by the cerebral vasculature. The …
[HTML][HTML] A pilot study investigating changes in capillary hemodynamics and its modulation by exercise in the APP-PS1 Alzheimer mouse model
Dysfunction in neurovascular coupling that results in a mismatch between cerebral blood
flow and neuronal activity has been suggested to play a key role in the pathogenesis of …
flow and neuronal activity has been suggested to play a key role in the pathogenesis of …
[HTML][HTML] Cerebral tissue pO2 response to treadmill exercise in awake mice
We exploited two-photon microscopy and Doppler optical coherence tomography to
examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in …
examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in …
Microscopic quantification of oxygen consumption across cortical layers
P Mächler, N Fomin-Thunemann, M Thunemann… - bioRxiv, 2021 - biorxiv.org
The cerebral cortex is organized in cortical layers that differ in their cellular density,
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
Response to Hypoxia in Cognitive Decline
JW Larrick, JW Larrick, AR Mendelsohn - Rejuvenation Research, 2021 - liebertpub.com
Inflammaging, the increase of proinflammatory processes with increasing age, has multiple
mechanisms from increasing numbers of senescent cells secreting cytokines to changes in …
mechanisms from increasing numbers of senescent cells secreting cytokines to changes in …