BACKGROUND The epididymis performs an important role in the maturation of spermatozoa
including their acquisition of progressive motility and fertilizing ability. However, the …

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin
signaling pathway. These proteins are approximately 35 kDa, and are characterized by two …

Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …

The Wnt/β-catenin signaling system plays essential roles in embryonic development and in
the self-renewal and maintenance of adult stem cells. R-spondins (RSPOs) are a group of …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

Molecular markers are used to characterize and track adult stem cells. Colon cancer
research has led to the identification of 2 related receptors, leucine-rich repeat–containing …

After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in
animal development. With the finding that the colorectal tumour suppressor gene APC is a …

Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …

The superfamily of G protein-coupled receptors (GPCRs) includes at least 800 seven-
transmembrane receptors that participate in diverse physiological and pathological …

The Wnt/β-catenin signaling pathbway controls many important biological processes. R-
Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β …