Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Emergence of form and function during embryogenesis arises in large part through cell-type-
and cell-state-specific variation in gene expression patterns, mediated by specialized cis …

The transcriptome contains rich information on molecular, cellular and organismal
phenotypes. However, experimental and statistical limitations constrain sensitivity and …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Although enhancers are crucial and widespread gene-regulatory elements, we are far from
a complete understanding of how they function or their importance in areas such as disease …

Over the last decade, development and application of a set of molecular genomic
approaches based on the chromosome conformation capture method (3C), combined with …

The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-
engineering due to its simplicity, flexibility and high efficiency. Recently, targeted knock-in of …

Long non-coding (lnc) RNAs can regulate gene expression and protein functions. However,
the proportion of lncRNAs with biological activities among the thousands expressed in …