Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

After induction and specification in the ectoderm, at the border of the neural plate, the neural
crest (NC) population leaves its original territory through a delamination process. Soon …

Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal
models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

Migration of hematopoietic stem cells through the blood, across the endothelial vasculature
to different organs and to their bone marrow (BM) niches, requires active navigation, a …

C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical …