Diverse inflammatory conditions, from infections to autoimmune disease, are often
associated with cellular damage and death. Apoptotic cell death has evolved to minimize its …

Our skin provides a physical and immunological barrier against dehydration and
environmental insults ranging from microbial attacks, toxins and UV irradiation to wounding …

Necroptosis is a caspase-independent modality of cell death implicated in many
inflammatory pathologies. The execution of this pathway requires the formation of a cytosolic …

Objective Receptor-interacting protein kinase 1 (RIPK1) orchestrates the decision between
cell survival and cell death in response to tumor necrosis factor (TNF) and other cytokines …

Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro
studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key …

Cells of the monocyte/macrophage lineage are an integral component of the body's innate
ability to restore tissue function after injury. In parallel to mounting an inflammatory …

Background Recent experimental studies of neuroinflammation in glaucoma pointed to
cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific …

Death receptor (DR) networks are controlled by the assembly of the Death-Inducing
Signaling Complex (DISC) and complex II. The family of small molecules FLIPins (FLIP …

Spatial nonuniformity in tight-binding models serves as a source of rich phenomena. In this
paper we study a diamond-chain tight-binding model with a spatially increasing magnetic …

The FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a
crucial role in various biological processes, including apoptosis and inflammation. However …