The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …

The earliest macrophages are generated during embryonic development from erythro-
myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process is thought …

Introduction Preeclampsia is a multisystemic, pregnancy-specific disorder united by new-
onset hypertension but with considerable variation in clinical manifestation, onset, and …

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global …

Maternal immune activation is associated with adverse offspring neurodevelopmental
outcomes, many mediated by in utero microglial programming. As microglia remain …

Placental fetal macrophages (fMacs) are the only immune cells on the fetal side of the
placental barrier. Mouse models have not been used to test their function because they have …

Background Preeclampsia is a pregnancy-specific disorder that always causes maternal
and fetal serious adverse outcome. Disturbances in maternal immune tolerance to embryo at …

Abstract Background The SARS-CoV-2 virus activates maternal and placental immune
responses. Such activation in the setting of other infections during pregnancy is known to …

Macrophages are an abundant cell population in the placenta and developing embryo and
appear to be involved in processes of vascularization, morphogenesis, organogenesis, and …