In Alzheimer's disease (AD), Aβ deposits form slowly, several decades before further
pathological events trigger neurodegeneration and dementia. However, a substantial …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Abstract Development of tau-based therapies for Alzheimer's disease requires an
understanding of the timing of disease-related changes in tau. We quantified the …

Early diagnosis of Alzheimer's disease plays a pivotal role in patient care and clinical trials.
In this study, we have developed a new approach based on 3D deep convolutional neural …

Background The order and magnitude of pathologic processes in Alzheimer's disease are
not well understood, partly because the disease develops over many years. Autosomal …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers …

In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …

Objectives: To investigate whether serum neurofilament light (NfL) concentration is
increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and …

Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …