Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

In chronic viral infections, CD8+ T cells become functionally deficient and display multiple
molecular alterations. In contrast, only little is known of self-and tumor-specific CD8+ T cells …

CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key
transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin …

Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …

Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …

BACKGROUND: CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural
killer (NK) cell, B-cell, and plasma cell function, survival, and differentiation. On the basis of …

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and
killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide …

Immunological memory and exhaustion are fundamental features of adaptive immunity.
Recent advances reveal increasing heterogeneity and diversity among CD8 T-cell subsets …

Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an
attractive approach to cancer therapy, with the potential to circumvent immune regulatory …