Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Chemokines and chemokine receptors orchestrate cell migration and homing in the body.
Humans have at least 44 chemokines that are further classified into four subfamilies based …

Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that
continually monitor the external environment, and in health, instruct tolerance to innocuous …

Through their functional diversification, distinct lineages of CD4+ T cells can act to either
drive or constrain immune-mediated pathology. Transcription factors are critical in the …

We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …

Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation.
The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is …