Enabling technology and core theory of synthetic biology

XE Zhang, C Liu, J Dai, Y Yuan, C Gao, Y Feng… - Science China Life …, 2023 - Springer
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

Advances and challenges in random access techniques for in vitro DNA data storage

Y Zhou, K Bi, Q Ge, Z Lu - ACS Applied Materials & Interfaces, 2024 - ACS Publications
With digital transformation and the general application of new technologies, data storage is
facing new challenges with the demand for high-density loading of massive information. In …

Sensitive small molecule aptasensing based on hybridization chain reaction and CRISPR/Cas12a using a portable 3D-printed visualizer

L Ma, D Liao, Z Zhao, J Kou, H Guo, X Xiong… - ACS …, 2023 - ACS Publications
Next-generation biosensing tools based on CRISPR/Cas have revolutionized the molecular
detection. A number of CRISPR/Cas-based biosensors have been reported for the detection …

DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access

BWA Bögels, BH Nguyen, D Ward, L Gascoigne… - Nature …, 2023 - nature.com
DNA has emerged as an attractive medium for archival data storage due to its durability and
high information density. Scalable parallel random access to information is a desirable …

A digital twin for DNA data storage based on comprehensive quantification of errors and biases

AL Gimpel, WJ Stark, R Heckel, RN Grass - Nature Communications, 2023 - nature.com
Archiving data in synthetic DNA offers unprecedented storage density and longevity.
Handling and storage introduce errors and biases into DNA-based storage systems …

FMG: An observable DNA storage coding method based on frequency matrix game graphs

B Cao, P Shi, Y Zheng, Q Zhang - Computers in Biology and Medicine, 2022 - Elsevier
Using complex biomolecules for storage is a new carbon-based storage method. For
example, DNA has the potential to be a good method for archival long-term data storage …

DNA as a universal chemical substrate for computing and data storage

S Yang, BWA Bögels, F Wang, C Xu, H Dou… - Nature Reviews …, 2024 - nature.com
DNA computing and DNA data storage are emerging fields that are unlocking new
possibilities in information technology and diagnostics. These approaches use DNA …

Advanced DNA amplification for efficient data storage

J Zhang, M Chen, G Lin, S Liu, C Yang… - ACS Applied Materials …, 2024 - ACS Publications
DNA amplification technologies have significantly advanced biotechnology, particularly in
DNA storage. However, adaptation of these technologies to DNA storage poses substantial …

Purification of multiplex oligonucleotide libraries by synthesis and selection

H Choi, Y Choi, J Choi, AC Lee, H Yeom, J Hyun… - Nature …, 2022 - nature.com
Complex oligonucleotide (oligo) libraries are essential materials for diverse applications in
synthetic biology, pharmaceutical production, nanotechnology and DNA-based data …

Robust data storage in DNA by de Bruijn graph-based de novo strand assembly

L Song, F Geng, ZY Gong, X Chen, J Tang… - Nature …, 2022 - nature.com
DNA data storage is a rapidly developing technology with great potential due to its high
density, long-term durability, and low maintenance cost. The major technical challenges …