Background Tobacco smoking is the leading preventable cause of death and disease
worldwide. Stopping smoking can reduce this harm and many people would like to stop …

Background Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes.
This helps to reduce cravings and withdrawal symptoms, and ease the transition from …

Background: Antidepressants are among the most commonly prescribed medications, but
evidence on comparative weight change for specific first-line treatments is limited. Objective …

Background This overview of reviews aims to identify evidence on the benefits (ie tobacco
use abstinence and reduction in smoking frequency) and harms (ie possible adverse …

Background: Governments around the world are considering regulating access to nicotine e-
cigarettes to prevent uptake among youth however people that smoke tobacco may use …

Abstract Concepts of suicide are explored in this issue with a focus on suicide in children
and adolescents. The epidemiology of pediatric suicide in the United States is reviewed; …

Bupropion is used for treating depression, obesity, and seasonal affective disorder, and for
smoking cessation. Bupropion is commonly prescribed, but has complex pharmacokinetics …

Preclinical models of addictive drugs have been developed for decades to model aspects of
the clinical experience in substance use disorders (SUDs). These include passive exposure …

Aims To summarise systematic reviews on tobacco addiction published by the Cochrane
Tobacco Addiction Group (CTAG) from 2021 to 2023. Methods We identified all new and …

METHODS This partially blind, single-center study randomized (1: 1) 361 participants into
two major groups. In the genetic group (n= 184), CYP2B6 rs2279343 (genotype AA) …