Fertility preservation in boys: recent developments and new insights

E Goossens, K Jahnukainen, RT Mitchell… - Human …, 2020 - academic.oup.com
BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Exposure to chemotherapy during childhood or adulthood and consequences on spermatogenesis and male fertility

M Delessard, J Saulnier, A Rives, L Dumont… - International journal of …, 2020 - mdpi.com
Over the last decade, the number of cancer survivors has increased thanks to progress in
diagnosis and treatment. Cancer treatments are often accompanied by adverse side effects …

Effects of paternal overnutrition and interventions on future generations

MM Billah, S Khatiwada, MJ Morris… - International journal of …, 2022 - nature.com
In the last two decades, evidence from human and animal studies suggests that paternal
obesity around the time of conception can have adverse effects on offspring health through …

What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines

N Rives, B Courbière, T Almont, D Kassab… - European Journal of …, 2022 - Elsevier
Aim To provide practice guidelines about fertility preservation (FP) in oncology. Methods We
selected 400 articles after a PubMed review of the literature (1987–2019) …

Fertility preservation for prepubertal boys: lessons learned from the past and update on remaining challenges towards clinical translation

C Wyns, M Kanbar, MG Giudice… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

The sperm centrioles

T Avidor-Reiss, A Carr, EL Fishman - Molecular and Cellular …, 2020 - Elsevier
Centrioles are eukaryotic subcellular structures that produce and regulate massive
cytoskeleton superstructures. They form centrosomes and cilia, regulate new centriole …

Haploid germ cells generated in organotypic culture of testicular tissue from prepubertal boys

F De Michele, J Poels, M Vermeulen… - Frontiers in …, 2018 - frontiersin.org
While in mice various studies have described the completion of spermatogenesis in vitro
using either organotypic culture of prepubertal testicular tissue or 3D culture of isolated cells …

Culture-space control is effective in promoting haploid cell formation and spermiogenesis in vitro in neonatal mice

K Hashimoto, H Odaka, Y Ishikawa-Yamauchi… - Scientific Reports, 2023 - nature.com
The classical organ culture method, in which tissue is placed at the gas‒liquid interphase, is
effective at inducing mouse spermatogenesis. However, due to reginal variations in the …

Testicular organoids: a new model to study the testicular microenvironment in vitro?

JP Alves-Lopes, JB Stukenborg - Human Reproduction Update, 2018 - academic.oup.com
BACKGROUND In recent decades, a broad range of strategies have been applied to model
the testicular microenvironment in vitro. These models have been utilized to study testicular …

3D bioprinting for organ and organoid models and disease modeling

AC Juraski, S Sharma, S Sparanese… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction 3D printing, a versatile additive manufacturing technique, has diverse
applications ranging from transportation, rapid prototyping, clean energy, and medical …