The surface design of titanium implants influences not only the local biological reactions but
also affects at least the clinical result in orthopaedic application. During the last decades …

Bio-functionalization means to endow biomaterials with bio-functions so as to make the
materials or devices more suitable for biomedical applications. Traditionally, because of the …

Immune reactions play important roles in determining the in vivo fate of bone substitute
materials, either in new bone formation or inflammatory fibrous tissue encapsulation. The …

This study describes the fabrication and characterization of three-dimensional (3-D) poly (ε-
caprolactone)(PCL) scaffolds with defined pore architectures prepared using the melt …

Increased titanium surface hydrophilicity has been shown to accelerate dental implant
osseointegration. Macrophages are important in the early inflammatory response to surgical …

This paper addresses a significant paradox in biomaterials science; biocompatibility
phenomena have been experienced and described for over 50 years but without an agreed …

The extracellular matrix is composed of a variety of proteins, polysaccharides, and
glycosaminoglycans that self-assemble into a hierarchical order of nanometer-to micrometer …

Mesenchymal stem/stromal cells (MSCs) serve as essential components of regenerative
medicine. Their destiny is influenced by the interaction of the cells with the external …

It is well known that biomaterial topography can exert a profound influence on various
cellular functions such as migration, polarization, and adhesion. With the development and …

Early establishment of integration between the implant and the surrounding bone tissue is
crucial for the long-term stability of orthopedic and dental implants. To this end, surface …