Metalloimmunology: The metal ion-controlled immunity
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …
all enzymes and are critically involved in virtually all fundamental biological processes …
CRAC channels and calcium signaling in T cell-mediated immunity
Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …
Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee
We report the updated classification of Inborn Errors of Immunity/Primary
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants
We compared whole-exome sequencing (WES) and whole-genome sequencing (WGS) in
six unrelated individuals. In the regions targeted by WES capture (81.5% of the consensus …
six unrelated individuals. In the regions targeted by WES capture (81.5% of the consensus …
Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
[HTML][HTML] The next-generation sequencing revolution and its impact on genomics
Genomics is a relatively new scientific discipline, having DNA sequencing as its core
technology. As technology has improved the cost and scale of genome characterization over …
technology. As technology has improved the cost and scale of genome characterization over …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
Ion channels in innate and adaptive immunity
Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-
17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ …
17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ …