Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer …
Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells
Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
Havoc in harmony: Unravelling the intricacies of angiogenesis orchestrated by the tumor microenvironment
SS Acharya, CN Kundu - Cancer Treatment Reviews, 2024 - Elsevier
Cancer cells merely exist in isolation; rather, they exist in an intricate microenvironment
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …
Near infrared-responsive quinacrine–gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells
Aim: This study aimed to determine if quinacrine–gold hybrid nanoparticles (QAuNPs)+ near-
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …