Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …
populations have an underlying predisposition to deficient insulin secretion, which has a key …
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
A Deprince, JT Haas, B Staels - Molecular metabolism, 2020 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
[HTML][HTML] Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury
The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …
available in different states of energy metabolism. Cardiac mitochondria sense substrate …
Pharmacologic glycemic management of type 2 diabetes in adults: 2020 update
L Lipscombe, S Butalia, K Dasgupta, DT Eurich… - Canadian Journal of …, 2020 - Elsevier
Methods The overarching goals and methodologic principles for the Diabetes Canada CPG
are unchanged from 2018 (2, 3). Leveraging the search methods and PICO questions used …
are unchanged from 2018 (2, 3). Leveraging the search methods and PICO questions used …
Insulin resistance and cancer: in search for a causal link
E Chiefari, M Mirabelli, S La Vignera… - International journal of …, 2021 - mdpi.com
Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …
Treatment of type 2 diabetes patients with heart conditions
Introduction While type 2 diabetes mellitus (T2DM) increases the risk of cardiac
complications, diabetes treatment choices may increase or decrease the rates of cardiac …
complications, diabetes treatment choices may increase or decrease the rates of cardiac …
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
Key characteristics of cardiovascular toxicants
L Lind, JA Araujo, A Barchowsky… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …
called key characteristics (KCs) was first developed to identify carcinogenic hazards …
Diabetes and Alzheimer's disease: might mitochondrial dysfunction help deciphering the common path?
MA Potenza, L Sgarra, V Desantis, C Nacci… - Antioxidants, 2021 - mdpi.com
A growing number of clinical and epidemiological studies support the hypothesis of a tight
correlation between type 2 diabetes mellitus (T2DM) and the development risk of …
correlation between type 2 diabetes mellitus (T2DM) and the development risk of …
Mitochondrial dysfunction and heart disease: critical appraisal of an overlooked association
G Bisaccia, F Ricci, S Gallina, A Di Baldassarre… - International Journal of …, 2021 - mdpi.com
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …