Life and death at the voltage-sensitive sodium channel: evolution in response to insecticide use

JG Scott - Annual review of entomology, 2019 - annualreviews.org
The voltage-sensitive sodium channel (VSSC) is a critical component of the insect nervous
system. Pyrethroids and DDT are insecticides that have been widely used, and they kill …

[HTML][HTML] Reversing insecticide resistance with allelic-drive in Drosophila melanogaster

B Kaduskar, RBS Kushwah, A Auradkar… - Nature …, 2022 - nature.com
A recurring target-site mutation identified in various pests and disease vectors alters the
voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or …

Rapid evolutionary change, constraints and the maintenance of polymorphism in natural populations of Drosophila melanogaster

A Glaser‐Schmitt, TJS Ramnarine… - Molecular …, 2024 - Wiley Online Library
Allele frequencies can shift rapidly within natural populations. Under certain conditions,
repeated rapid allele frequency shifts can lead to the long‐term maintenance of …

A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population

JD Lange, H Bastide, JB Lack… - Molecular Biology and …, 2022 - academic.oup.com
Population genetics seeks to illuminate the forces shaping genetic variation, often based on
a single snapshot of genomic variation. However, utilizing multiple sampling times to study …

Drosophila melanogaster as a powerful tool for studying insect toxicology

JG Scott, N Buchon - Pesticide Biochemistry and Physiology, 2019 - Elsevier
Insecticides are valuable and widely used tools for the control of pest insects. Despite the
use of synthetic insecticides for> 50 years, we continue to have a limited understanding of …

Selective sweeps in a nutshell: the genomic footprint of rapid insecticide resistance evolution in the almond agroecosystem

B Calla, M Demkovich, JP Siegel… - Genome Biology and …, 2021 - academic.oup.com
Among the most familiar forms of human-driven evolution on ecological time scales is the
rapid acquisition of resistance to pesticides by insects. Since the widespread adoption of …

Mutation of the Cytochrome P450 CYP360A8 Gene Increases Sensitivity to Paraquat in Daphnia magna

P Religia, ND Nguyen, QD Nong… - Environmental …, 2021 - Wiley Online Library
The freshwater crustacean Daphnia magna has traditionally been a model for
ecotoxicological studies owing to its sensitivity to many xenobiotics. Because it is used in …

Conservation of the voltage‐sensitive sodium channel protein within the Insecta

JJ Silva, JG Scott - Insect molecular biology, 2020 - Wiley Online Library
The voltage‐sensitive sodium channel (VSSC) is essential for the generation and
propagation of action potentials. VSSC kinetics can be modified by producing different splice …

Resistance to Multiple Insecticide Classes in the Vinegar Fly Drosophila melanogaster (Diptera: Drosophilidae) in Michigan Vineyards

Z Hubhachen, H Pointon, JA Perkins… - Journal of Economic …, 2022 - academic.oup.com
Vinegar flies are vectors of pathogens causing fruit rots of grapes, so control of these insects
is important for preventing vineyard yield loss. Recent outbreaks of sour rots may be linked …

Genomic and transcriptomic analyses in Drosophila suggest that the ecdysteroid kinase-like (EcKL) gene family encodes the 'detoxification-by-phosphorylation' …

JL Scanlan, RS Gledhill-Smith, P Battlay… - Insect Biochemistry and …, 2020 - Elsevier
Phosphorylation is a phase II detoxification reaction that, among animals, occurs near
exclusively in insects, but the enzymes responsible have never been cloned or otherwise …