Herpes simplex viruses-1 and-2 (HSV-1 and-2) are two of the three human
alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in …

Drugs that contain phosphates (and phosphonates or phosphinates) have intrinsic
absorption issues and are therefore often delivered in prodrug forms to promote their uptake …

We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …

Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …

We report on the synthesis and characterization of three types of nucleoside tetraphosphate
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …

The development of new antiviral agents such as nucleoside analogues or acyclic
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …

Two convergent approaches for synthesizing a new class of nucleoside diphosphate
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …

Nucleoside reverse transcriptase inhibitors (NRTIs) are widely used as antiviral and
anticancer agents, although they require intracellular phosphorylation into their antivirally …

Nucleoside analogues are widely used as anti-infectious and antitumoral agents. However,
their clinical use may face limitations associated with their physicochemical properties …