Increasing evidence supports that cellular dysregulations in the degradative routes
contribute to the initiation and progression of neurodegenerative diseases, including …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

The precise mechanisms that lead to cognitive decline in Alzheimer's disease are unknown.
Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to …

The sensing of microbial genetic material by leukocytes often elicits beneficial pro-
inflammatory cytokines, but dysregulated responses can cause severe pathogenesis …

Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

Summary Bis (monoacylglycero) phosphate (BMP) is an abundant lysosomal phospholipid
required for degradation of lipids, particularly gangliosides. Alterations in BMP levels are …

The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity
towards lipids or endo-and exonuclease activity towards nucleic acids. PLD3 is synthesized …

Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic
catabolism of various macromolecules to small basic building blocks. These low‐molecular …

The endolysosomal system comprises a dynamic constellation of vesicles working together
to sense and interpret environmental cues and facilitate homeostasis. Integrating …

Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an
intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has …